T activity is essential for notochord formation, notochord differentiation and NMP maintenance (Cambray and Wilson, 2002, 2007; Henrique et al., 2015; Koch et al., 2017; Martin and Kimelman, 2010; Tsakiridis and Wilson, 2015; Tzouanacou et al., 2009). In NMPs, T and the signal molecule Wnt3a form a positive-feedback loop essential for axis elongation and mesodermal lineage choice, the latter in antagonism with the pro-neural activity of Sox2 (Garriock et al., 2015; Koch et al., 2017; Martin and Kimelman, 2008, 2012; Turner et al., 2014). As pan-mesodermal lineage control factor T plays an important role in remodeling the epigenome from the progenitor state to a mesodermal identity, and controls mesodermal transcription factors such as Tbx6 and Msgn1, which are essential for paraxial mesoderm differentiation (Chalamalasetty et al., 2014; Hofmann et al., 2004; Koch et al., 2017; Wittler et al., 2007). The formation and maintenance of the node and notochord require a high level of T expression (Pennimpede et al., 2012; Stemple, 2005; Zhu et al., 2016). The dual essential role of T in NMPs and node/notochord demonstrate that T is the central transcription factor coordinating the organization of the progenitors and their descendants shaping the trunk and tail.
High Tail Hall 2 Full 37
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We find ourselves beset by difficulties and hindrances. Suddenly there is a turn of affairs, as if someone were coming up with a horse and wagon and unhitching them. This event comes so unexpectedly that we assumethe newcomer to be a robber. Gradually it becomes clear that he has noevil intentions but seeks to be friendly and to offer help. But this offeris not to be accepted, because it does not come from the right quarter.We must wait until the time is fulfilled; ten years is a fulfilled cycleof time. Then normal conditions return of themselves, and we can join forceswith the friend intended for us. Using the image of a betrothed girl whoremains true to her lover in face of grave conflicts, the hexagram givescounsel for a special situation. When in times of difficulty a hindranceis encountered and unexpected relief is offered from a source unrelatedto us, we must be careful and not take upon ourselves any obligations entailedby such help; otherwise our freedom of decision is impaired. If we bideour time, things will quiet down again, and we shall attain what we havehoped for.
The head is the beginning. If the beginning is not right, there is no hope of a right ending. If we have missed the right moment for union and go on hesitating to give complete and full devotion, we shall regret the error when it is too late.
It is the law of heaven to make fullness empty and to make full what is modest; when the sun is at its zenith, it must, according to the law of heaven, turn toward its setting, and at its nadir it rises toward anew dawn. In obedience to the same law, the moon when it is full beginsto wane, and when empty of light it waxes again. This heavenly law worksitself out in the fates of men also. It is the law of earth to alter thefull and to contribute to the modest. High mountains are worn down by thewaters, and the valleys are filled up. It is the law of fate to underminewhat is full and to prosper the modest. And men also hate fullness andlove the modest. The destinies of men are subject to immutable laws thatmust fulfill themselves. But man has it in his power to shape his fate,according as his behavior exposes him to the influence of benevolent orof destructive forces. When a man holds a high position and is neverthelessmodest, he shines with the light of wisdom; if he is in a lowly positionand is modest, he cannot be passed by. Thus the superior man can carry outhis work to the end without boasting of what he has achieved.
The hexagram as a whole points to a time of joyous, hopeful progress. Spring is approaching. Joy and forbearance bring high and low nearertogether. Success is certain. But we must work with determination andperseverance to make full use of the propitiousness of the time. And onthing more: spring does not last forever. In the eighth month the aspectsare reversed. Then only two strong, light lines are left; these do notadvance but are in retreat (see next hexagram). We must take heed of thischange in good time. If we meet evil before it becomes reality-before ithas even begun to stir-we can master it.
Here at the highest stage of development all ornament is discarded. Form no longer conceals content but brings out its value to the full.Perfect grace consists not in exterior ornamentation of the substance,but in the simple fitness of its form.
Conditions are such that the hostile forces favored by the time are advancing. In this case retreat is the right course, and it is not tobe confused with flight. Flight means saving oneself under any circumstances, whereas retreat is a sign of strength. We must be careful not to missthe right moment while we are in full possession of power and position.Then we shall be able to interpret the signs of the time before it is toolate and to prepare for provisional retreat instead of being drawn intoa desperate life-and-death struggle. Thus we do not simple abandon thefield to the opponent; we make it difficult for him to advance by showingperseverance in single acts of resistance. In this way we prepare, whileretreating, for the counter-movement. Understanding the laws of a constructiveretreat of this sort is not easy. The meaning that lies hidden in sucha time is important.
The high plateau is dry and unsuitable for the wild goose. If it goes there, it has lost its way and gone too far. This is contrary to thelaw of development. It is the same in human life. If we do not let thingsdevelop quietly but plunge of our own choice too rashly into a struggle,misfortune results. A man jeopardizes his own life, and his family perishesthereby. However, this is not all necessary; it is only the result oftransgressing the law of natural development. If one does not willfullyprovoke a conflict, but confines himself to vigorously maintaining hisown position and to warding off unjustified attacks, all goes well.
The conditions are difficult. The task is great and full of responsibility. It is nothing less than that of leading the world out of confusion back to order. But it is a task that promises success, because there is a goal that can unite the forces now tending in different directions. At first, however, one must move warily, like an old fox walking over ice. The caution of a fox walking over ice is proverbial in China. His ears are constantly alert to the cracking of the ice, as he carefully and circumspectly searches out the safest spots. A young fox who as yet has not acquired this caution goes ahead boldly, and it may happen that he falls in and gets his tailwet when he is almost across the water. Then of course his effort has beenall in vain. Accordingly, in times "before completion," deliberation andcaution are the prerequisites of success.
No person shall drive a vehicle on a highway at a speed greater than is reasonable and prudent under the conditions. Every driver is responsible for becoming and remaining aware of the actual and potential hazards then existing on the highway and must use due care in operating a vehicle. In every event speed shall be so restricted as may be necessary to avoid colliding with any person, vehicle or other conveyance on or entering the highway in compliance with legal requirements and the duty of all persons to use due care.
(a) The driver of any vehicle shall, consistent with the requirements, drive at an appropriate reduced speed when approaching or passing an authorized emergency vehicle stopped with emergency lights flashing on any street or highway, when approaching and crossing an intersection or railway grade crossing, when approaching and going around a curve, when approaching a hill crest, when traveling upon any narrow or winding roadway, and when special hazards exist with respect to pedestrians or other traffic or by reason of weather or highway conditions.
(b) A person who fails to reduce speed appropriately when approaching or passing an authorized emergency vehicle stopped with emergency lights flashing on a street or highway shall be assessed an additional surcharge equal to the amount of the fine imposed for the speed violation, but not less than $25.
On determining upon the basis of an engineering and traffic investigation that any speed set forth in this section is greater or less than is reasonable or safe under the conditions found to exist on any trunk highway or upon any part thereof, the commissioner may erect appropriate signs designating a reasonable and safe speed limit thereat, which speed limit shall be effective when such signs are erected. Any speeds in excess of such limits shall be prima facie evidence that the speed is not reasonable or prudent and that it is unlawful; except that any speed limit within any municipality shall be a maximum limit and any speed in excess thereof shall be unlawful. On determining upon that basis that a part of the trunk highway system outside a municipality should be a zone of maximum speed limit, the commissioner may establish that part as such a zone by erecting appropriate signs showing the beginning and end of the zone, designating a reasonable and safe speed therefor, which may be different than the speed set forth in this section, and that it is a zone of maximum speed limit. The speed so designated by the commissioner within any such zone shall be a maximum speed limit, and speed in excess of such limit shall be unlawful. The commissioner may in the same manner from time to time alter the boundary of such a zone and the speed limit therein or eliminate such zone.
When local authorities believe that the existing speed limit upon any street or highway, or part thereof, within their respective jurisdictions and not a part of the trunk highway system is greater or less than is reasonable or safe under existing conditions, they may request the commissioner to authorize, upon the basis of an engineering and traffic investigation, the erection of appropriate signs designating what speed is reasonable and safe, and the commissioner may authorize the erection of appropriate signs designating a reasonable and safe speed limit thereat, which speed limit shall be effective when such signs are erected. Any speeds in excess of these speed limits shall be prima facie evidence that the speed is not reasonable or prudent and that it is unlawful; except that any speed limit within any municipality shall be a maximum limit and any speed in excess thereof shall be unlawful. Alteration of speed limits on streets and highways shall be made only upon authority of the commissioner except as provided by law. 2ff7e9595c
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